TRANSLATIONAL PHYSIOLOGY Branched-chain amino acids increase p70 phosphorylation in human skeletal muscle after resistance exercise
نویسندگان
چکیده
Håkan K. R. Karlsson,* Per-Anders Nilsson,* Johnny Nilsson, Alexander V. Chibalin, Juleen R. Zierath, and Eva Blomstrand Department of Health and Sport Sciences, University College of Physical Education and Sports, Stockholm S-114 86; Section Integrative Physiology, Department of Surgical Sciences, Karolinska Institute, Stockholm, S-171 77; and Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, S-171 76, Sweden
منابع مشابه
Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.
The aim of the study was to investigate the effect of resistance exercise alone or in combination with oral intake of branched-chain amino acids (BCAA) on phosphorylation of the 70-kDa S6 protein kinase (p70(S6k)) and mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and p38 MAPK in skeletal muscle. Seven male subjects performed one session of quadriceps m...
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Amino acids and insulin have anabolic effects in skeletal muscle, but the mechanisms are poorly understood. To test the hypothesis that leucine and insulin stimulate translation initiation in human skeletal muscle by phosphorylating 70-kDa ribosomal protein S6 kinase (p70(S6k)), we infused healthy adults with leucine alone (n = 6), insulin alone (n = 6), or both leucine and insulin (n = 6) for ...
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